Abstractftz is one of the ‘pair rule’ segmentation genes of Drosophila melanogaster, and is an important component of the segmentation process in the fruit fly. We discuss the transcriptional mechanism which causes ftz to be expressed in a seven stripe pattern during embryogenesis.

ExcerptCarl Schmitt (1888–1985) is known as the most consequential German legal and political mind of the twentieth century.1 Many crimes of the Nazi regime found support in his conceptual justifications, and Schmitt is called the “Crown Jurist” of the Third Reich with good reason. Historians, political scientists, and sociologists must grapple with the author in order to understand the course of totalitarianism in modernity. Whether literary historians should do so is far less settled, though he was fascinated by their object (...) of study. His writings on literary topics are said to reveal much about Schmitt’s person, politics, and period, but little about literature itself.2 This explains why his “Don Quijote und das Publikum” (“Don Quixote and the Public”), published in the arts and cultural journal Die Rheinlande in 1912, was almost unknown in literary studies for a century.3 Schmitt’s text on the novel by Miguel de Cervantes has not been reprinted, and until recently it had not been translated from the original German. Size has a role too. At under two thousand words, the text has probably escaped notice due to its small scale.4 Recent English and Italian translations in major humanistic journals may signal the end of its obscurity though.5 “Don Quixote and the Public” is at the door of literary studies. The question now is not whether to respond, but how. (shrink)

This paper suggests an alternative reading of Practice in Christianity to Merold Westphal’s interpretation of the text as defining what he calls “religiousness C.” Attending closely to the rhetorical construction of Practice, and situating it in the context of Kierkegaard’s intensive reading of Luther late in his life, I argue that this text extends the Postscript’s meditation on inwardness and writing to one of the central theological constructs of Lutheranism, the distinction between law and gospel. On my reading, Practice both (...) defends the primacy of faith and grace within Christianity, and refuses their commodification into directly communicable results. At the end of this paper, I consider Kierkegaard’s seeming retraction, in 1855, of two rhetorical features of Practice that my reading emphasizes. Iconclude that this gesture in fact intensifies Kierkegaard’s appropriation of the law/gospel paradigm, and speaks to the impossibility of any direct, comprehensive, and final account of authentic Christian life. (shrink)

Programmed cell death is a critical part of normal development, removing obsolete tissues or cells and sculpting body parts to assume their appropriate form and function. Most programmed cell death occurs by apoptosis of individual cells or autophagy of groups of cells. Although these pathways have distinct morphological characteristics, they also have a number of features in common, suggesting some overlap in their regulation. A recent paper by Lee and Baehrecke provides further support for this proposal.(1) These authors present, for (...) the first time, a genetic analysis of autophagy, using the steroid‐triggered metamorphosis of Drosophila as a model system. They demonstrate a remarkable degree of overlap between the control of apoptosis and autophagy as well as a key role for the steroid‐inducible gene E93 in directing the autophagic death response. This paper also shows that E93 can direct cell death independently from the known death‐inducer genes, defining a novel death pathway in Drosophila. BioEssays 23:677–682, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

English translations of three major narrative poems and ten shorter texts written in the 14th and 13th centuries B.C.E. in what is now Syria and Lebanon, where they were discovered on tablets in the second quarter of the 20th century. Parallel columns match transliteration of the original cuneiform with line-by-line translation. The texts are supported by introductions, textual (rather than historical or literary) annotations, and a glossary mostly of place and personal names without pronunciation guides. Paper edition (unseen), $14.95. Annotation (...) copyrighted by Book News, Inc., Portland, OR. (shrink)

At least seven orphan members of the nuclear receptor superfamily are transcriptionally regulated by the steroid hormone ecdysone and expressed during the onset of Drosophila metamorphosis. A recent paper provides functions for two of these receptors, E75B and DHR3, through trans‐regulation and heterodimerization(1). DHR3 appears to function as a switch that defines the transition from a late larva to a prepupa, and E75B functions as a timer that modulates this transition. This study provides a biological function for orphan receptor interactions (...) during development. (shrink)

Sixteen years ago, Michael Ashburner and his colleagues proposed a hierarchical model for the genetic control of polytene chromosome puffing by the steroid hormone ecdysone. The recent molecular isolation and characterization of three early ecdysone‐inducible genes has confirmed many aspects of this model — these genes are directly induced by ecdysone, repressed by ecdysone‐induced proteins, and appear to encode DNA binding regulatory proteins. The three early genes are also remarkably similar in structure. They are all unusually long and complex, with (...) multiple transcripts that direct the synthesis of several related proteins from each locus. Proteins encoded by two of the early genes bind to both early and late ecdysone‐induced puffs, implying that they are key regulators in the hierarchy. (shrink)

Lloyd (2009) contends that climate models are confirmed by various instances of fit between their output and observational data. The present paper argues that what these instances of fit might confirm are not climate models themselves, but rather hypotheses about the adequacy of climate models for particular purposes. This required shift in thinking—from confirming climate models to confirming their adequacy-for-purpose—may sound trivial, but it is shown to complicate the evaluation of climate models considerably, both in principle and in practice.

Recently, the outsourcing of Information Technology activities to offshore locations has been gaining significant momentum, with some associated backlash by the workforce in the United States. Based on their 2005 survey [6], Global Insight, a private consulting firm, estimated that U.S. companies will spend about $38.2 billion in offshore IT services by 2010, compared with about $15.2 billion in 2005, primarily because the expected cost savings will grow by $11.7 billion in the same time period. Binder writing in "Foreign Affairs" (...) [2] states that offshoring expenditures will continue to increase dramatically, and the changes the offshoring phenomenon will bring will transform society. This paper focuses on the social impact of offshoring and the effects of the weighing of costs and benefits as a result of offshoring activities. (shrink)

Thermodynamics is the foundation of many of the topics of interest in the religion‐science dialogue. Here a nonmathematical outline of the principles of thermodynamics is presented, providing a historical and conceptually understandable development that can serve teachers from disciplines other than physics. The contributions of Gibbs to both classical and rational thermodynamics, emphasizing the importance of the ensemble in statistical mechanics, are discussed. The seminal ideas of Boltzmann on statistical mechanics are contrasted to those of Gibbs in a discussion of (...) the microscopic interpretation of the second law. The role of information theory is discussed, and the modern ideas of Prigogine and nonequilibrium are outlined in some detail with further reference to the second law. Implications for our interaction with God are considered. (shrink)

The quantum‐measurement problem and the Heisenberg indeterminacy principle are presented in the language of the Dirac formulation of the quantum theory. Particularly the relationship between quantum state prior to measurement and the result of the measurement are discussed. The relation between the indeterminacy principle and the analog between quantum and classical systems is presented, showing that this principle may be discussed independently of the wave‐particle duality. The importance of statistics in the treatment of many body systems is outlined and the (...) approach to investigating God's interaction with human beings is discussed in this context. The treatment is nonmathematical. (shrink)

Abstract.The basic laws of physics for particles and fields can be formulated in terms of variational principles. The initial development of a variational principle had distinct teleological implications. The formulation of physical laws in terms of variational principles is outlined with specific reference to classical and quantum mechanics and field theory. Because of time irreversibility no variational principle exists for thermodynamics. In order to obtain time irreversibility molecular trajectories must be abandoned in the lowest‐level description of complex multicomponent systems. A (...) more open set of possibilities results. I suggest that this may be more consistent with a modern teleology. (shrink)

John Polkinghorne is a significant contributor to the religion and science dialogue, bringing the expertise of a scientist coupled with serious theological study, ordination, and service as a parish priest. He takes both theology and science with utmost seriousness and describes himself as a bottom‐up thinker, confronting the scriptural record as a scientist does data. But he refrains from giving scientific explanations of scripture. Polkinghorne's concern is with hope, and specifically with eschatological hope. The framework for his theological thinking is (...) the Nicene Creed, in which is found the counterintuitive openness common to theoretical physics. He acknowledges the need for thinking beyond the confines of present scientific understanding in proposing active information as a concept for considering the mind. (shrink)

Ursula Coope's volume sets out to answer the question of why "true freedom" necessitates "freedom from bodies" according to the Neoplatonists. As a result, while the title suggests a work on ethics, the volume handles such questions within a broader metaphysical framework. Coope admirably traces the initially separate treatments of freedom and responsibility in earlier thinkers before examining how they merge into twin aspects of a related discussion. The handling of Plato's concept of freedom in the first chapter outlines a (...) series of relevant issues, rather than evaluating their relative significance, since the primary focus is on the subsequent tradition. The title is somewhat misleading since much of the... (shrink)

Completeness is an important but misunderstood norm of explanation. It has recently been argued that mechanistic accounts of scientific explanation are committed to the thesis that models are complete only if they describe everything about a mechanism and, as a corollary, that incomplete models are always improved by adding more details. If so, mechanistic accounts are at odds with the obvious and important role of abstraction in scientific modelling. We respond to this characterization of the mechanist’s views about abstraction and (...) articulate norms of completeness for mechanistic explanations that have no such unwanted implications. _1_ Introduction _2_ A Balancing Act: When Do Details Matter? _3_ The Norms of Causal Explanation _4_ The Norms of Constitutive Explanation _5_ Salmon-Completeness _6_ From More Details to More Relevant Details _7_ Non-explanatory Virtues of Abstraction _8_ From Explanatory Models to Explanatory Knowledge _9_ Mechanistic Completeness Reconsidered _10_ Conclusion. (shrink)

Many areas of science develop by discovering mechanisms and role functions. Cummins' (1975) analysis of role functions-according to which an item's role function is a capacity of that item that appears in an analytic explanation of the capacity of some containing system-captures one important sense of "function" in the biological sciences and elsewhere. Here I synthesize Cummins' account with recent work on mechanisms and causal/mechanical explanation. The synthesis produces an analysis of specifically mechanistic role functions, one that uses the characteristic (...) active, spatial, temporal, and hierarchical organization of mechanisms to add precision and content to Cummins' original suggestion. This synthesis also shows why the discovery of role functions is a scientific achievement. Discovering a role function (i) contributes to the interlevel integration of multilevel mechanisms, and (ii) provides a unique, contextual variety of causal/mechanical explanation. (shrink)

An adequate understanding of the ubiquitous practice of mechanistic explanation requires an account of what Craver termed “constitutive relevance.” Entities or activities are constitutively relevant to a phenomenon when they are parts of the mechanism responsible for that phenomenon. Craver’s mutual manipulability account extended Woodward’s account of manipulationist counterfactuals to analyze how interlevel experiments establish constitutive relevance. Critics of MM argue that applying Woodward’s account to this philosophical problem conflates causation and constitution, thus rendering the account incoherent. These criticisms, we (...) argue, arise from failing to distinguish the semantic, epistemic, and metaphysical aspects of the problem of constitutive relevance. In distinguishing these aspects of the problem and responding to these critics accordingly, we amend MM into a refined epistemic criterion, the “matched interlevel experiments” account. Further, we explain how this epistemological thesis is grounded in the plausible metaphysical thesis that constitutive relevance is causal betweenness. (shrink)

Organizational change surrounding the security of identifiable health information has become imperative. This is a significant challenge for managers who are held responsible for loss of privacy through faulty security procedures. Management cannot completely secure the organization and still provide employees and customers with the information and services they need. Organizations must decide how much and what type of security they need, how to assign priorities, and how to manage security as the organization evolves in a competitive environment.

It is a common assumption in contemporary cognitive neuroscience that discovering a putative realized kind to be dissociably realized (i.e., to be realized in each instance by two or more distinct realizers) mandates splitting that kind. Here I explore some limits on this inference using two deceptively similar examples: the dissociation of declarative and procedural memory and Ramachandran's argument that the self is an illusion.

This paper first distinguishes three alternative views that adherents to both incompatibilism and PAP may take as to what constitutes an agent''s determining or controlling her action (if it''s not the action''s being deterministically caused by antecedent events): the indeterministic-causation view, the agent-causation view, and "simple indeterminism." The bulk of the paper focusses on the dispute between simple indeterminism - the view that the occurrence of a simple mental event is determined by its subject if it possesses the "actish" phenomenal (...) quality and is undetermined by antecedent events - and Timothy O''Connor''s agent-causation view. It defends simple indeterminism against O''Connor''s objections to it and offers objections to O''Connor''s view. (shrink)

Climate change fingerprint studies investigate the causes of recent climate change. I argue that these studies have much in common with Steel’s (2008) streamlined comparative process tracing, illustrating a mechanisms-based approach to extrapolation in which the mechanisms of interest are simulated rather than physically instantiated. I then explain why robustness and variety-of-evidence considerations turn out to be important for understanding the evidential value of climate change fingerprint studies.

An electron clearly has the property of having a charge of þ1.6 10 19 coulombs, but does it also have the property of being charged ? Philosophers have worried whether so-called ‘determinable’ predicates, such as ‘is charged’, actually refer to determinable properties in the way they are happy to say that determinate predicates, such as ‘has a charge of þ1.6 10 19 coulombs’, refer to determinate properties. The distinction between determinates and determinables is itself fairly new, dating only to its (...) definition by the Cambridge logician W. E. Johnson early in the last century.1 But despite its newly minted condition the distinction has found little currency in on-going philosophical debates. Or at least until recently. Renewed interest in realist positions about properties, and arguments that the determinable-determinate relation may hold the key to understanding mental causation, have thrust Johnson’s distinction to the fore. With this new attention has also come new ‘optimistic’ positions that endorse the existence of determinable properties. David Armstrong, Evan Fales, and Sydney Shoemaker, among others, have all defended such optimistic accounts that take determinable predicates, such as ‘is charged’, to refer to determinable properties.2 In this paper, our goal is to carefully assess optimism and to argue that a pessimistic view, which rejects the existence of determinable properties, is actually the appropriate default position. (shrink)

A core, constitutive norm of science is to remove or remedy the artefacts in one’s data. Here, we consider examples of artefacts from many fields of science (for example, astronomy, economics, electrophysiology, psychology, and systems neuroscience) and discuss their contribution to a more general evidential selection problem at the heart of the epistemology of evidence. Synthesizing and building on previously disparate discussions in many areas of the philosophy of science, we provide a novel, causal–pragmatic account that fits the examples and (...) clarifies the practices by which artefacts are discovered and remedied. (shrink)

This chapter identifies conditions under which robust predictive modeling results have special epistemic significance—related to truth, confidence, and security—and considers whether those conditions are met in the context of climate modeling today. The findings are disappointing. When today’s climate models agree that an interesting hypothesis about future climate change is true, it cannot be inferred, via the arguments considered here anyway, that the hypothesis is likely to be true, nor that confidence in the hypothesis should be significantly increased, nor that (...) a claim to have evidence for the hypothesis is now more secure. In some other modeling contexts, the prospects for such arguments are brighter. (shrink)

In After God: Morality and Bioethics in a Secular Age, H. Tristram Engelhardt, Jr. explores the broad implications for moral reasoning once a culture has lost a God’s-eye perspective. In this paper, I focus on the implications of Engelhardt’s views for clinical ethics consultation. I begin by examining the question of whether clinical ethics consultants should advocate a particular viewpoint and/or process during consultations or adopt a neutral stance. I then examine the implications of Engelhardt’s views for this question. Finally, (...) I discuss some of Engelhardt’s foundational ontological, metaphysical, meta-ethical, and epistemological commitments and how these commitments connect to his views on clinical ethics consultation. (shrink)

This book comprises eleven essays in the philosophy of action, six of which were previously published. The book has a fairly extensive index. The essays are arranged in four groups. The first group contains two essays on the individuation of action. The second contains four essays that argue for the view that what makes an event an action is, not how it is caused, but that it is, or begins with, a volition, “an intrinsically actional” mental event. The third contains (...) three essays that defend the view that free and responsible action is incompatible with determinism, largely by arguing for a noncausal account of reasons explanation of action. The final group contains two essays on intention formation and rationality; the first argues that it is sometimes rational to form intentions that are inconsistent with each other or with one’s beliefs; the second argues that an important sort of practical reasoning has as its conclusion the forming of an intention for action, rather than the adopting of a belief as to what one should do. (shrink)

The concept of vulnerability has long played a central role in discussions of research ethics. In addition to its rhetorical use, vulnerability has become a term of art in U.S. and international research regulations and guidelines, many of which contain specific provisions applicable to research with vulnerable subjects. Yet, despite the frequency with which the term vulnerability is used, little consensus exists on what it actually means in the context of human subject protection or, more importantly, on how a finding (...) of vulnerability should affect the process of research ethics review.The Common Rule, the centerpiece of the U.S. human subject protection regulations, uses the word vulnerable three times. First, it provides that institutional review boards that regularly review research involving a vulnerable category of subjects should consider including one or more individuals who are knowledgeable about and experienced in working with these subjects. (shrink)

Stephan Blatti claims to have a new line of reasoning using evolutionary theory that resolves arguments over our deeper natures in favor of the Animalist position that we are identical to Homo sapiens organisms. Blatti thus raises an important question about which views of what we are can take us to be evolved. However, in this response I show that Blatti’s argument using evolution is based upon a false assumption about contemporary biology. I highlight how a better understanding of evolutionary (...) theory allows us to see that the major theories of what we are, including Psychological, Brain and even Soul theories, as well as Animalism, can all accept that we are products of evolution. (shrink)

In order to involve children in the decision-making process about participation in medical research it is widely recommended that the child’s assent be sought in addition to parental consent. However, the concept of assent is fraught with difficulties, resulting in confusion among researchers and ethics committees alike.

This paper critically examines Weisberg’s weighted feature matching account of model-world similarity. A number of concerns are raised, including that Weisberg provides an account of what underlies scientific judgments of relative similarity, when what is desired is an account of the sorts of model-target similarities that are necessary or sufficient for achieving particular types of modeling goal. Other concerns relate to the details of the account, in particular to the content of feature sets, the nature of shared features and the (...) assumed independence of feature weightings. (shrink)

This article identifies conditions under which robust predictive modeling results have special epistemic significance---related to truth, confidence, and security---and considers whether those conditions hold in the context of present-day climate modeling. The findings are disappointing. When today’s climate models agree that an interesting hypothesis about future climate change is true, it cannot be inferred---via the arguments considered here anyway---that the hypothesis is likely to be true or that scientists’ confidence in the hypothesis should be significantly increased or that a claim (...) to have evidence for the hypothesis is now more secure. (shrink)

What are the relative epistemic merits of building prosthetic models versus building nonprosthetic models and simulations? I argue that prosthetic models provide a sufficient test of affordance validity, that is, of whether the target system affords mechanisms that can be commandeered by a prosthesis. In other respects, prosthetic models are epistemically on par with nonprosthetic models. I focus on prosthetics in neuroscience, but the results are general. The goal of understanding how brain mechanisms work under ecologically and physiologically relevant conditions (...) is narrow compared to the search for maker's knowledge about how the brain can be made to work for us. (shrink)

This paper presents a computational model that integrates a dynamically structured holographic memory system into the ACT-R cognitive architecture to explain how linguistic representations are encoded and accessed in memory. ACT-R currently serves as the most precise expression of the moment-by-moment working memory retrievals that support sentence comprehension. The ACT-R model of sentence comprehension is able to capture a range of linguistic phenomena, but there are cases where the model makes the wrong predictions, such as the over-prediction of retrieval interference (...) effects during sentence comprehension. Here, we investigate one such case involving the processing of sentences with negative polarity items and consider how a dynamically structured holographic memory system might provide a cognitively plausible and principled explanation of some previously unexplained effects. Specifically, we show that by replacing ACT-R's declarative memory with a dynamically structured memory, we can explain a wider range of behavioral data involving reading times and judgments of grammaticality. We show that our integrated model provides a better fit to human error rates and response latencies than the original ACT-R model. These results provide proof-of-concept for the unification of two independent computational cognitive frameworks. (shrink)